The LexArts HOP is a wonderful, FREE opportunity to appreciate and celebrate Lexington's art. There are many new gallery exhibitions, special events, and food and drinks that will being going on downtown from 5-8pm Nov. 20th. For more information visit the link below.
To have this count as a Wired event, please post a selfie to the Wired LLP Facebook group!
Adrian Matejka's first collection of poems, The Devil’s Garden, won the 2002 New York / New England Award from Alice James Books. His second collection, Mixology (Penguin 2009), was a winner of the 2008 National Poetry Series and was a finalist for a NAACP Image Award for Outstanding Literature – Poetry. His most recent book, The Big Smoke, was awarded the 2014 Anisfield-Wolf Book Award and was also finalist for the 2013 National Book Award and for the 2014 Pulitzer Prize in Poetry. Matejka is a winner of the Julia Peterkin Award and recipient of two Illinois Arts Council Literary Awards and fellowships from the Guggenheim Foundation and the Lannan Foundation. He teaches in the MFA program at Indiana University in Bloomington.
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Dr. Bob Sauer from the Massachusetts Institute of Technology will be presenting a seminar titled Machines of Protein Destruction.
Abstract
In all domains of life, AAA+ family proteolytic machines eliminate unnecessary or damaged intracellular proteins and help to regulate biological circuits. The operation of these ATP-dependent machines depends upon a AAA+ ring hexamer with a central axial channel or pore, which engages an unstructured region of a target protein. Conformational changes in the ring, powered by cycles of ATP hydrolysis, pull on and eventually denature the substrate, and the unfolded polypeptide is subsequently translocated through the pore and into the chamber of an associated self-compartmentalized peptidase for degradation. AAA+ proteases can be used to create truncated proteins with biological activities that differ from the intact molecule, and AAA+ ring enzymes also function biologically to remodel macromolecular complexes. For ClpXP, the best studied AAA+ protease, ClpX is the AAA+ enzyme and ClpP is the peptidase. Recent single-molecule studies have revealed how ClpX unfolds model substrates, how it translocates them into ClpP, and how these activities differ for a protease in which ClpA, a double-ring AAA+ hexamer, replaces ClpX. This work, crystallographic studies, and biochemical experiments have led to detailed models of structure and function, which will be discussed.
Faculty Host: Yinan Wei
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The GSA will host the Chemistry Department Halloween Potluck from 11:30am to 1:00pm. The entire department is invited!
UK Appalachian Studies Director and Professor of Sociology, Dr. Shaunna Scott will present her work as a recipient of a UK Appalachian Center 2015 Eller Billings Mini Grant on Wednesday, November 18, 2015 from 12 p.m. to 1:30 p.m. This SWAP (Sharing Work on Appalachia in Progress) Event is free, and students, faculty, and staff are welcome and encouraged to attend! Dr. Scott's talk is entitled From Collaboration to Network Analysis: A Viable Option to Assist a Community in its Post-Coal Development. The event will be held at the UK Appalachian Center, 624 Maxwelton Court, and lunch will be provided.
Please, join us for this free event! Two of our 2015 Eller Billings Mini Grant recipients will share their work on Thursday, November 5, 2015 from 12 p.m. to 1:30 p.m. at the UK Appalachian Center, 624 Maxwelton Court. Sara Beth Freytag is a student in the Master's Program in the Department of Forestry; her talk title is Effects of Mountaintop Removal Mining on Population Dynamics of Stream Salamanders. Jasper Waugh Quasebarth is a Ph.D. student in the Department of Anthropology; his talk title is Finding the Singing Spruce: Locating Material in West Virginian Musical Instrument Craft. Lunch will be provided, and students, faculty and staff are welcome!
Title of talk: Relaxations of the matroid axioms.
Qualifying Exam: A unified approach to the Euler-Mahonian identity.
Current and prospective graduate affiliates are invited to join the Committee on Social Theory for North Lime coffee and donuts, Friday October 23rd at 10am in 1643 Patterson Office Tower. Come with questions about the Social Theory certificate, gradate courses, and the Social Theory journal, disClosure.
