Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors.
| Author | |
| Abstract |
:
Several reported effects of acamprosate within the glutamatergic system could result from interactions with metabotropic glutamate receptors (mGluRs). The following experiments were performed to determine whether acamprosate could compete with trnas-ACPD (+/--1-aminocyclopentane-trans-1,3-dicarboxylic acid, an equimolecular mixture of 1S, 3R and 1R, 3S-ACPD and an agonist at both group I and group II mGluRs) sensitive binding sites and protect against trans-ACPD-induced neurotoxicity in organotypic hippocampal slice cultures. |
| Year of Publication |
:
2002
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| Journal |
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Alcoholism, clinical and experimental research
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| Volume |
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26
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| Issue |
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12
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| Number of Pages |
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1779-93
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| ISSN Number |
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0145-6008
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| DOI |
:
10.1097/01.ALC.0000042011.99580.98
|
| Short Title |
:
Alcohol Clin Exp Res
|
| Download citation |
