Recent advances in both experimental and theoretical atomic, molecular, and optical physics provide remarkable new opportunities for precision measurements and tests of fundamental physics, including searches for permanent electric-dipole moments, parity violation studies, searches for variation of fundamental constants, testing gravity and searching for gravitational waves, tests of local Lorentz invariance and the Einstein equivalence principle and many others. I will give a systematic overview of searches for new physics with atoms and molecules, recent key results, and highlight select future proposals.