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Clinical impact of pharmacokinetic interactions between the HCV protease inhibitor Simeprevir and frequently used concomitant medications.

Author
Abstract
:

Direct-acting antivirals (DAAs) for the treatment of hepatitis C (HCV) can be associated with drug-drug interactions (DDIs) with concomitant medications. The practical clinical implications of such DDIs are poorly understood. We assessed the clinical impact of possible pharmacokinetic (PK) interactions between simeprevir and frequently prescribed concomitant medications.

Year of Publication
:
2018
Journal
:
British journal of clinical pharmacology
Date Published
:
2018
ISSN Number
:
0306-5251
URL
:
http://dx.doi.org/10.1111/bcp.13519
DOI
:
10.1111/bcp.13519
Short Title
:
Br J Clin Pharmacol
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