Differential role of PTEN in transforming growth factor β (TGF-β) effects on proliferation and migration in prostate cancer cells.
| Author | |
|---|---|
| Abstract |
:
Transforming growth factor-β (TGF-β) acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. PI3-kinase pathway mediates TGF-β effects on prostate cancer cell migration and invasion. PTEN inhibits PI3-kinase pathway and is frequently mutated in prostate cancers. We investigated possible role(s) of PTEN in TGF-β effects on proliferation and migration in prostate cancer cells. |
| Year of Publication |
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2018
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| Journal |
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The Prostate
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| Date Published |
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2018
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| ISSN Number |
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0270-4137
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| DOI |
:
10.1002/pros.23482
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| Short Title |
:
Prostate
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| Download citation |
