Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex.
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| Abstract |
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Inhibitors of the enzyme catechol-O-methyltransferase (COMT) are used as co-adjuvants in the therapy of Parkinson's disease. A recombinant form of the soluble cytosolic COMT from rat has been co-crystallized with a new potent inhibitor, BIA 8-176 [(3,4-dihydroxy-2-nitrophenyl)phenylmethanone], by the vapour-diffusion method using PEG 6K as precipitant. Crystals diffract to 1.6 A resolution on a synchrotron-radiation source and belong to the monoclinic space group P2(1), with unit-cell parameters a = 52.77, b = 79.63, c = 61.54 A, beta = 91.14 degrees. |
| Year of Publication |
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1969
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| Journal |
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Acta crystallographica. Section F, Structural biology and crystallization communications
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| Volume |
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61
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| Issue |
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Pt 1
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| Number of Pages |
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118-20
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| Date Published |
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2005 Jan 1
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| URL |
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http://scripts.iucr.org/cgi-bin/paper?S1744309104031197
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| DOI |
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10.1107/S1744309104031197
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| Short Title |
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Crystallization and preliminary Xray diffraction studies of a ca
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