Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.
| Author | |
|---|---|
| Abstract |
:
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis. |
| Year of Publication |
:
2004
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| Journal |
:
Antiviral research
|
| Volume |
:
61
|
| Issue |
:
1
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| Number of Pages |
:
67-70
|
| ISSN Number |
:
0166-3542
|
| URL |
:
https://linkinghub.elsevier.com/retrieve/pii/S0166354203001840
|
| DOI |
:
10.1016/j.antiviral.2003.08.002
|
| Short Title |
:
Antiviral Res
|
| Download citation |
