Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
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| Abstract |
:
Chemotherapy-induced cognitive impairment (CICI) is a common sequelae of cancer therapy. Recent preclinical observations have suggested that CICI can be mediated by chemotherapy-induced plasma protein oxidation, which triggers TNF-α mediated CNS damage. This study evaluated sodium-2-mercaptoethane sulfonate (Mesna) co-administration with doxorubicin to reduce doxorubicin-induced plasma protein oxidation and resultant cascade of TNF-α, soluble TNF receptor levels and related cytokines. |
| Year of Publication |
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0
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| Journal |
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PloS one
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| Volume |
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10
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| Issue |
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4
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| Number of Pages |
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e0124988
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| Date Published |
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2015
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| URL |
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https://dx.plos.org/10.1371/journal.pone.0124988
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| DOI |
:
10.1371/journal.pone.0124988
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| Short Title |
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PLoS One
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| Download citation |
