Skip to main content

The Linear No-Threshold Model of Low-Dose Radiogenic Cancer: A Failed Fiction.

Author
Abstract
:

The linear no-threshold (LNT) model for low-dose, radiogenic cancer has been a fixture of radiation protection and regulatory requirements for decades, but its validity has long been contested. This article finds, yet again, more questionable data and analyses purporting to support the model, this within the "gold-standard" data set for estimating radiation effects in humans. Herein is addressed a number of significant uncertainties in the Radiation Effects Research Foundation's Life Span Study (LSS) cohort of atomic bomb survivors, especially in its latest update of 2017, showing that the study's support of the LNT model is not evidence based. We find that its latest 2 analyses of solid cancer incidence ignore biology and do not support the LNT model. Additionally, we identify data inconsistencies and missing causalities in the LSS data and analyses that place reliance on uncertain, imputed data and apparently flawed modeling, further invalidating the LNT model. These observations lead to a most credible conclusion, one supporting a threshold model for the dose-response relationship between low-dose radiation exposure and radiogenic cancer in humans. Based upon these findings and those cited from others, it becomes apparent that the LNT model cannot be scientifically valid.

Year of Publication
:
1969
Journal
:
Dose-response : a publication of International Hormesis Society
Volume
:
17
Issue
:
1
Number of Pages
:
1559325818824200
Date Published
:
1969
URL
:
https://journals.sagepub.com/doi/abs/10.1177/1559325818824200?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
:
10.1177/1559325818824200
Short Title
:
Dose Response
Download citation