Locking plate fixation strength relies on axial alignment of the screw axis and plate hole, with small deviations in alignment substantially decreasing the load to failure. In an effort to overcome this technical deficiency, polyaxial locking plates were designed to provide increased flexibility of screw positioning with the intent of not sacrificing fixation strength. The purpose of this article is to review the variety of polyaxial locking mechanisms currently available, to compare the biomechanical performance of these designs, and to highlight their differences, which may have clinical implications.