Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study.
| Author | |
|---|---|
| Abstract |
:
Tumour-targeted fluorescence imaging has the potential to advance current practice of oncological surgery by selectively highlighting malignant tissue during surgery. Carcinoembryonic antigen (CEA) is overexpressed in 90% of colorectal cancers and is a promising target for colorectal cancer imaging. We aimed to assess the tolerability of SGM-101, a fluorescent anti-CEA monoclonal antibody, and to investigate the feasibility to detect colorectal cancer with intraoperative fluorescence imaging. |
| Year of Publication |
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2018
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| Journal |
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The lancet. Gastroenterology & hepatology
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| Date Published |
:
2018
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| URL |
:
http://linkinghub.elsevier.com/retrieve/pii/S2468-1253(17)30395-3
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| DOI |
:
10.1016/S2468-1253(17)30395-3
|
| Short Title |
:
Lancet Gastroenterol Hepatol
|
| Download citation |
