Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT<sub>1A</sub> receptor.

TitleDifferential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT1A receptor.
Publication TypeJournal Article
Year of Publication2017
JournalPsychopharmacology
Volume234
Issue6
Pagination1029-1043
ISSN0033-3158
Abstract

Cannabinoid CB1 inverse agonists hold therapeutic promise as appetite suppressants but have produced suicidal behaviors among a small subpopulation in clinical trials. Anatomical and pharmacological evidence implicate the 5HT1A serotonin receptor in suicide in humans and impulsivity in humans and animals.

URLhttps://dx.doi.org/10.1007/s00213-017-4548-2
DOI10.1007/s00213-017-4548-2
Short TitlePsychopharmacology (Berl)
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