The bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.

TitleThe bed nucleus of the stria terminalis is critically involved in enhancing associative learning after stressful experience.
Publication TypeJournal Article
Year of Publication2005
JournalBehavioral neuroscience
Volume119
Issue6
Pagination1459-66
ISSN0735-7044
Abstract

Exposure to an acute stressful event enhances trace eyeblink conditioning in male rats, even when rats begin training days after the stressor (Shors, 2001). The authors examined whether the bed nucleus of the stria terminalis (BNST), an area involved in stress and anxiety, is critically involved in this effect and, if so, when. The authors found that excitotoxic lesions to the BNST prevented the enhanced conditioning after stressor exposure. In addition, temporary inactivation of the BNST during the stressor did not alter enhanced responding, whereas inactivation during training prevented the enhancement. These data indicate that stressful experience induces persistent changes in the BNST that are necessary for enhancing learning well after the stressful event has ceased.

URLhttp://content.apa.org/journals/bne/119/6/1459
DOI10.1037/0735-7044.119.6.1459
Short TitleBehav Neurosci
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