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Biological Chemistry Seminar

Date:
-
Location:
CP-114B

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Xiaojia Ren will be presenting a revised version of last week's seminar--Does doxorubicin-induced TNF alpha elevation cause chemobrain?

Abstract:Doxorubicin is an anti-cancer drug, mainly being used to tread solid tumor and leukimia. It can produce reactive oxygen species by the nature of its quinone structure which can be converted to semiquinone and get back to quinone with superoxide anion producing. Dox induced ROS will cause oxidative stress in plasma and further lead to lipidperoxidation and elevation of TNF alpha, which can across BBB to activate glia in brain to make more TNF alpha, causing mitochodria damage and leading to apoptosis and finally leading to cognitive impairment. We hyposisize that TNF alpha plays an important role in potential mechanism for chemotherapy-induced cognitive impairment (CICI) that occurs with ROS producing anticancer drug using Doxorubicin as an example.

In this way to build reasonable prevention and improve quality of life of cancer patients by outlining the potential mechanisms for anticancer drug induced CICI.
 

Course Instructor: Dr. Anne-Frances Miller